Compounds 7, 8, and 10 showed relevant cytotoxic activity against these cancer cell lines, and 10 showed a protective effect against lipid peroxidation. Lipid peroxidation on rat brain was also tested for compounds 7 and 10. The cytotoxic screening of 7, 8, 9, and 10 at 50 and 10 µg/mL was carried out with human cancer cell lines K562, MCF-7, and SKLU-1. The main structural feature of these compounds is the reverse linkage of the two aromatic moieties, where the acid chloride moiety is linked to the phenolic group while preserving α, β-unsaturated ketone functionality. ![]() A family of new compounds that mimic the structure of curcumin and curcuminoids, here named retro-curcuminoids ( 7– 14), was synthesized and characterized using 1D 1H- and 13C-NMR, IR, and mass spectrometry the X-ray structure of 7, 8, 9, 10, 12, 13, and 14 are reported here for the first time. Curcumin and its derivatives have been extensively studied for their remarkable medicinal properties, and their chemical synthesis has been an important step in the optimization of well-controlled laboratory production.
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